Share cases and questions with Physicians on Medscape consult. BMD is caused by dys … Becker muscular dystrophy (BMD) is a condition which causes weakness in the muscles. [Medline]. This can limit your movement and even lead to pain. When contractures have advanced, surgery may be performed to relieve them. Stephen Kishner, MD, MHA Professor of Clinical Medicine, Physical Medicine and Rehabilitation Residency Program Director, Louisiana State University School of Medicine in New Orleans Read about the promise of stem cell research for muscular dystrophy patients, and successful treatments tested in dogs. 434(1):[Medline]. BMD is an inherited disease with a male distribution pattern and a clinical picture similar to that of Duchenne muscular dystrophy (DMD). 2011 Nov 8. Life expectancy and death from cardiomyopathy amongst carriers of Duchenne and Becker muscular dystrophy in Scotland. Possible future treatments for BMD include the following: Gene therapy may eventually lead to effective treatment, given proper identification of the gene defect and effective administration of the corrective gene to the muscle targets. The dystrophinopathies Duchenne and Becker muscular dystrophies (DMD and BMD) represent the most common inherited disorders of muscle. Supplementing vitamin D and calcium is also recommended. Due to dystrophin gene deficiency, its severity is unpredictable. Treatment options include medications, physical and occupational therapy, and surgical and other procedures. 2008 Feb. 10(1):86-94. Because no cure exists for BMD, treatment is focused on controlling a patient's symptoms. Almost exclusively affect boys. Dystrophin deficiency can cause some cognitive problems in some people. 3.2. Becker muscular dystrophy (BMD) is an inherited condition that causes progressive weakness and wasting of the skeletal and cardiac (heart) muscles. Treatment. Ashton EJ, Yau SC, Deans ZC, et al. Becker muscular dystrophy usually affects boys and men. Pediatrics. Symptoms of Becker MD usually begin in childhood, but they're often relatively mild at this point. Becker muscular dystrophy is in the category of inherited muscle wasting diseases caused by a gene abnormality (mutation) that results in deficient or abnormal production of the dystrophin protein (dystrophinopathies). Avoid obesity. 2011 Nov 15. Medications belonging to a group known as corticosteroids – or glucocorticoids –  have been found effective in slowing the course of DMD. Dysphagia concerns may be evaluated by a speech therapist. [Medline]. Medications that lessen the workload on the heart are sometimes prescribed for BMD. Eur Heart J Cardiovasc Imaging. Some people with BMD ultimately require wheelchairs or scooters. There’s currently no cure for muscular dystrophy, but treatments can help manage your symptoms and slow the progression of the disease. Gurvich OL, Tuohy TM, Howard MT, et al. Kat Kolaski, MD Assistant Professor, Departments of Orthopedic Surgery and Pediatrics, Wake Forest University School of Medicine Cardiomyopathy, which means deterioration of the heart muscle, is common in BMD. Much of the pioneering research into a treatment for Duchenne muscular dystrophy may also benefit those with Becker muscular dystrophy. The American Academy of Pediatrics recommends that those with BMD have cardiac evaluations at least every other year beginning at age 10 or even earlier. Adolesc Health Med Ther. The impact of BMD can be significantly minimized by keeping the body as flexible, upright, and mobile as possible. Physical activity is important for those who have this disease, as bed rest can cause BMD to worsen. Your MDA Care Center physician will refer you to a physical therapist for a thorough evaluation and recommendations. Muscular Dystrophy News is strictly a news and information website about the disease. [Medline]. Becker muscular dystrophy (DIS-trah-fee), or BMD, is a genetic disease affecting different groups of muscles in the body. Occupational therapy focuses on specific activities and functions, such as work tasks, recreation, driving, dressing, or using a computer. Becker's muscular dystrophy is an X-linked inherited muscular dystrophy with the disorder occurring at locus Xp21.2. But in muscular dystrophy, too much exercise could damage cardiac and skeletal muscle. Constipation may be an associated problem, given poor fluid intake and progressive difficulty with commode transfers. Outside Organization Programs & Information, Taking the Reins of Your Medical Care and Participating in Clinical Trials, adverse reactions to certain types of anesthesia, Functional Treatment Considerations: Orthotics. It is a genetic condition and it is caused by a fault in a gene called dystrophin. 2018. 2013 Aug 15. [Medline]. Young HK, Barton BA, Waisbren S, et al. Becker MD also affects similar areas of the body to Duchenne MD, although the symptoms tend to be less severe. 6. Becker muscular dystrophy (BMD) has a similar presentation to DMD but a relatively milder clinical course. Subspecialty consultations depend on the patient's specific needs as related to the disorder. 9:53-63. Andrews JG, Wahl RA. Patients with constipation, gastroesophageal reflux, or gastrointestinal motility problems should be referred to a gastroenterologist. Appropriate consultations may include the following: Anesthesiologist - Preoperative management and planning for appropriate anesthesia are key reasons for consultation with an anesthesiologist. Clin Genet. This type of muscular dystrophy likewise more typically impacts young boys, according to iytmed.com. Becker muscular dystrophy (BMD) is a genetic disorder characterized by progressive weakness and degeneration of the skeletal muscles that control movement. It does not provide medical advice, diagnosis, or treatment. This helps prevent tightened tendons and muscles. BMD can present in several ways such as waddling gait, exercise related cramps with or without myoglobinuria. Risk of fracture in patients with muscular dystrophies. As different types of MD can cause quite specific problems, the treatment you receive will be tailored to your needs. Osteoporos Int. The primary goals of physical therapy are to allow greater motion in the joints and to prevent contractures and scoliosis (spinal curvature). Inherited neuromuscular disorders: Pathway to diagnosis. Like Duchenne MD, Becker MD mostly affects boys. This type is characterized by progressive weakness and loss of muscle mass in the cardiac and skeletal muscles. [28, 29]. Some men need a wheelchair, while others may only need walking aids such as canes or braces. [22]. Becker muscular dystrophy (BMD) has onset usually in childhood, frequently by 11 years. 2011 Nov. 48(11):731-6. Spinal fusion to correct scoliosis may be scheduled based on the progression of spinal deformity and the age of the patient. J Child Neurol. [Full Text]. [Medline]. 1994 Jul. Physical activity is important for those who have this disease, as bed rest can cause BMD to worsen. [Medline]. People with BMD may have unexpected adverse reactions to certain types of anesthesia. Becker Muscular Dystrophy Treatment. Angelini C, Fanin M, Pegoraro E, et al. This can be treated by a noninvasive strategy known as bilevel positive airway pressure (BiPAP). Heel cord release is a commonly performed joint contracture procedure. 193(4):427-48. Functional Treatment Considerations: Occupational and Physical Therapy. Symptoms most often appear in boys between ages 5 and 15, but may begin later. Therapy & Treatment. Improvements in cardiac care, attention to respiratory function, and judicious use of spinal correction surgery have led to increased survival in the DMD population. The risk of malignant hyperthermia is significant, given the intrinsic muscle disorder. Patients are given supportive care, leg braces and physiotherapy to help them function in daily life. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. In some cases, Becker muscular dystrophy can lead to life-threatening health problems, as heart and breathing muscles weaken. The progressive loss of safe swallowing may result in the need for gastrostomy tube placement. 4. As of 2019, most therapies are supportive in nature, although truly disease-modifying therapies are the subject of intense research. Loss of balance and coordination. Both Duchenne and Becker muscular dystrophies are caused by an abnormal gene carried on the X sex chromosome. Symptoms of Becker MD usually begin in childhood, but they're often relatively mild at this point. Adaptive physical education programs and disabled student services are generally available for qualified individuals. Ankle-foot orthoses are sometimes prescribed for night wear to keep feet from pointing downward and keep the Achilles tendon stretched. Educational institutions, from public schools to community colleges and universities, may have resources that can be utilized. 313417-overview Health Qual Life Outcomes. No definitive evidence demonstrates that steroids are effective against BMD. Privacy Policy | Terms of Use | State Fundraising Notices. Becker Muscular Dystrophy. Part II. 2013 Sep. 23(9):855-64. Some experts recommend swimming and water exercises (aquatic therapy) as a good way to keep muscles as toned as possible without causing undue stress on them. Other aspects of Duchenne and Becker muscular dystrophy are reviewed separately. 2011 Nov 3. The academy suggests that carriers should undergo a complete cardiac evaluation in late adolescence or early adulthood, or sooner if symptoms occur, and should be evaluated frequently. Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr. It is vital that a person with BMD stay in shape and continue to use their muscles. [Medline]. BMD is caused by a … Early interventions may focus on stretching tight muscles (which may initially be the only therapy goal). Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector. There is no cure for muscular dystrophy and no way to stop it from getting worse. This can include physical therapy. After walking ability is lost - wheelchairs and other aids. Becker muscular dystrophy (BMD) generally leads to slowly worsening disability, but the amount of disability can vary among affected people. Becker muscular dystrophy is similar to Duchenne muscular dystrophy, but it’s less severe. About Becker Muscular Dystrophy Becker muscular dystrophy is a rare, genetic, degenerative disease that causes progressive muscle weakening and loss, primarily affecting skeletal and cardiac muscles. [3] 2. The abnormal gene is called DMD and is located on the X chromosome. Generally, walking difficulties begin after the age of 16. Revising Cardiac Care in Muscular Dystrophies, DMD Clinical Research Network Studying Dystrophin-Deficient Heart, Cardiac Complications and Management in BMD, Nutritional Considerations While on Corticosteroids, Nutritional Needs in Neuromuscular Disease, Functional Considerations: Occupational and Physical Therapy. Heart. Although there's no cure for any form of muscular dystrophy, treatment for some forms of the disease can help extend the time a person with the disease can remain mobile and help with heart and lung muscle strength. Paediatr Anaesth. The challenge is to determine whether the weakness is originating in the muscles themselves or in the motor neurons (branching from the spinal cord), which control these muscles. Clinical-molecular correlation in 104 mild X-linked muscular dystrophy patients: characterization of sub-clinical phenotypes. J Neurol Sci. Glucocorticoid treatment and potential disease-modifying therapies for Duchenne and Becker muscular dystrophy will be discussed in this review. Orthopedist - The need for management of scoliosis and joint contractures are major indications for consultation with an orthopedist. [Medline]. Duchenne and Becker muscular dystrophy: Treatment & Research. It will also depend on how severe the condition is. 1-5. Identifying mosaicism in the mother or father, as well as determining the risk of transmission, is another topic to consider in nonheterozygote carrier families or in isolated cases. Genetic testing will confirm the diagnosis of Duchenne and Becker and show the exact mutation in the gene. This type of muscular dystrophy likewise more typically impacts young boys, according to iytmed.com. 2021, Muscular Dystrophy Association Inc. All rights reserved. Becker muscular dystrophy is like Duchenne, except milder. Homeopathy Treatment for Muscular Dystrophy The symptoms and weaknesses of the muscular dystrophy can be … Duan D. Myodys, a full-length dystrophin plasmid vector for Duchenne and Becker muscular dystrophy gene therapy. As with DMD, there is muscle wasting and weakness which is mainly proximal. The aim of gene therapy is to deliver DNA encoding dystrophin or other therapeutic genes, such as utrophin, to muscle. Genetic faults in the same gene are also the cause of the more severe form of muscle weakness called Duchenne muscular dystrophy (DMD). The goal of treatment is to control symptoms to maximize the person's quality of life. The impact of BMD can be significantly minimized by keeping the body as flexible, upright, and mobile as possible. However, the condition is closely related to Duchenne muscular dystrophy. Most people who have Becker muscular dystrophy (BMD) receive treatments similar to those people who have Duchenne muscular dystrophy (DMD). 5. Privacy Policy | It usually appears between the ages of 2 and 16 but can appear up to the age of 25. Restoration of the Dystrophin-associated Glycoprotein Complex After Exon Skipping Therapy in Duchenne Muscular Dystrophy. Muscle cramps may be helped by night splints, massage or compression treatment using air-filled boots. As the patient's weakness progresses, appropriate equipment and assistive devices will be required to enable the individual to maintain functional mobility and independence in daily living activities. Diseases & Conditions, encoded search term (Becker Muscular Dystrophy) and Becker Muscular Dystrophy, Physical Medicine and Rehabilitation for Limb-Girdle Muscular Dystrophy, Certifying Medical Cannabis: What APRNs Need to Know, FDA OKs Viltolarsen (Viltepso) for Duchenne Muscular Dystrophy, Ataluren Delays Disease Milestones in Patients With Nonsense Mutation DMD, Myopathies: Muscling Your Way to the Diagnosis, Convicted Ex-Surgeon Pleads Guilty to New Fraud Charges, FDA Approves Implant as Alternative to ACL Reconstruction, Epidural Corticosteroid Injections for Sciatica, Increased Risk of Bone Fractures in Non-meat Eaters, Spinal Epidural Abscess: Diagnosis, Management, and Outcomes. Because disease pro-gression and treatment plans differ between the two disorders, a BMD diagnosis should be confirmed with genetic testing. Rutkove SB, Darras BT. … Symptomatic patients with significant cardiomyopathy have undergone transplantation procedures. Exercise can help build skeletal muscle, keep the cardiovascular system healthy and contribute to feeling better. Because dystrophin is lacking or missing from all the muscles, many body functions are involved and need attention from different medical subspecialists. Becker muscular dystrophy symptoms and effects develop slowly, with symptoms appearing between ages 5 and 15. It is important that a health professional be available to help coordinate care for anyone with muscular dystrophy. Weakness progresses, and emergencies related to cardiac and respiratory symptoms are hallmarks of advance in the disease process. It has been shown that prednisone therapy can be helpful for patients diagnosed with BMD as well.2 However, little is known about the effect of the benefits of glucocorticosteroid (a class of corticosteroid) for BMD patients. If not treated, these can become severe, causing discomfort and restricting mobility and flexibility. Treatment is supportive and includes: 1. There’s some evidence that treatment with angiotensin converting enzyme (ACE) inhibitors and beta blockers can slow the course of cardiac muscle deterioration in BMD if the medications are started as soon as abnormalities on an echocardiogram (imaging of the heart) appear, but before symptoms occur. To view an August 2012 video presentation on this topic, see Functional Treatment Considerations: Orthotics. Muscular Dystrophy News is strictly a news and information website about the disease. 2007. The disease is found mostly in boys. Simultaneous mutation scanning for gross deletions, duplications and point mutations in the DMD gene. Elizabeth A Moberg-Wolff, MD is a member of the following medical societies: American Academy for Cerebral Palsy and Developmental Medicine, American Academy of Physical Medicine and RehabilitationDisclosure: Nothing to disclose. Becker PE, Kiener F. [A new x-chromosomal muscular dystrophy.]. Currently there is no known cure for Becker muscular dystrophy. [Full Text]. Currently there is no known cure for Becker muscular dystrophy. If you log out, you will be required to enter your username and password the next time you visit. What is Becker muscular dystrophy? Rev Can Biol. for: Medscape. Nicolas A, Raguenes-Nicol C, Ben Yaou R, et al. Diagnosis is suggested clinically and is confirmed by genetic testing or analysis of the protein product (dystrophin) of the mutated gene. To deliver DNA encoding dystrophin or other therapeutic genes, such as utrophin, to muscle to types. Beta-Blockers ) can protect the heart are sometimes prescribed for night wear to keep muscles as strong as possible progressive. View an August 2012 video on this topic, see functional treatment Considerations: occupational and physical therapy be... The start of glucocorticoid treatment with DMD, there is currently no cure for Becker muscular:! The lower legs help keep a patient walking for as long as possible major. 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