ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. They have a large surface area relative to their size and high catalytic activity. The Food and Drug Administration (FDA) has recognized ZnO as safe due to its lack of or very weak dark toxicity in vitro and in vivo (Hu et al. HeLa cell spheroids were cultured and the spheroids allowed to form prior to nanoparticle treatment and were exposed to ZnO NP at 10 or 20 ug/ml concentration respectively in serum containing media and photographed at time 0, 24 and 5 days by light … The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. Therefore, ZnO NPs as a novel agent in order for zinc delivery have been developed and evaluated for their antidiabetic potential. The particle sizes of zinc oxide nanoparticles were determined by AFM (AFM, SPM-9500J3, Shimadzu CO., Japan) and Zetasizer Nano-ZS90 (Malvern Instruments) by the method of Du et al. Typical researches about biological imaging of ZnO NPs. The zinc oxide nanoparticles are commonly used in cosmetics industry like sun screen lotions due to its UV purifying properties (Wodka et al., 2010).The zinc oxide nanoparticles has wide range of biomedical applications. The nano-sized zinc oxide (Z n O) nanoparticles act as reinforcements and added in A357 alloys to fabricating aluminum nano composite. By means of the experimental study, PMMA-PEG/ZnO nanocomposites with the average size less than 80 nm could release curcumin more quickly in the acidic conditions at pH ∼5.8. Recently, nanomaterial-based nanomedicine, with high biocompatibility, easily surface functionalization, cancer targeting, and drug delivery capacity, has demonstrated the potential to overcome these side effects. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. The anticancer activity of ZnO NPs in different cancers is presented in Table 1. Diabetes mellitus is a metabolic disease caused by the body’s incapacity to produce insulin or by the ineffective use of the insulin produced [100, 101]. Wiegand explored the role of ZnO-functionalized textile fibers in the control of oxidative stress in AD in vitro and in vivo [114]. Aiming at the development of nanomedicine against cholera, Sarwar et al. The bulk zinc oxide (BZnO) groups were administered 5 mg/kg (BZnO-1) and 10 mg/kg (BZnO-2), correspondingly. We are committed to sharing findings related to COVID-19 as quickly as possible. Abstract Biosynthesis of zinc oxide nanoparticles (ZnO-NPs) was achieved by utilizing the reducing and capping potential of leaf, stem and callus aqueous extracts of Mussaenda frondosa. 2013). SEM images of the ZnO nanoparticles synthesized using Cassava … Daily intake of zinc via food is needed to carry out the regular metabolic functions. Therefore, studying it deeply has a lot of important theoretical and realistic value. E-mail: Hence, ZnO NPs also have the potential to be utilized for anti-inflammatory treatment. or in a thesis or dissertation provided that the correct acknowledgement is given Zinc oxide nanoparticles (ZnO-NPs) are widely used in almost every area of life. There are safety concerns related to 2014; 78-79: 49-52. of the whole article in a thesis or dissertation. constructed ZnO nanosheets for the imaging of cultured cells. The anti-inflammatory activity of ZnO NPs is not confined to atopic dermatitis treatment but has also shown to be very effective for other inflammatory diseases. Zinc oxide nanoparticles (ZnO NPs) also have remarkable optical, physical, and antimicrobial properties and therefore have great potential to enhance agriculture. In order to increase the targeting effects and selectivity against cancer cells, plenty of functionalization techniques have been reported for nanoparticle modification. Chandrasekaran and Pandurangan investigated the cytotoxicity of ZnO nanoparticles against cocultured C2C12 myoblastoma cancer cells and 3T3-L1 adipocytes, which showed that ZnO NPs could be more cytotoxic to C2C12 myoblastoma cancer cells than 3T3-L1 cells. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. Interaction ZnO NPs with HT1080 cell has relatively higher ROS generation. Methods and Results: ZnO NP with sizes of 70 nm and concentrations of 0, 3, 6 and 12 mmol l)1 and NP-free solutions were used in antimicrobial tests against E. coli O157:H7. (2008). The importance of zinc as a trace metal in the human body has long been overlooked. These results afforded valuable insights into the mechanism of ZnO NPs-induced apoptosis in human liver HepG2 cells. The results were summarized that ZnO NPs completely resisted the growth of E. coli at concentrations of about 3.4 mM but inhibited growth of S. aureus at much lower concentrations (≥1 mM). A. Ruszkiewicz, A. Pinkas, B. Ferrer, T. V. Peres, A. Tsatsakis, and M. Aschner, “Neurotoxic effect of active ingredients in sunscreen products, a contemporary review,”, A. Kolodziejczak-Radzimska and T. Jesionowski, “Zinc oxide–from synthesis to application: a review,”, S. Sahoo, M. Maiti, A. Ganguly, J. J. George, and A. K. Bhowmick, “Effect of zinc oxide nanoparticles as cure activator on the properties of natural rubber and nitrile rubber,”, M. D. Newman, M. Stotland, and J. I. Ellis, “The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens,”, A. Hatamie, A. Khan, M. Golabi et al., “Zinc oxide nanostructure-modified textile and its application to biosensing, photocatalysis, and as antibacterial material,”, F. X. Xiao, S. F. Hung, H. B. Tao, J. Miao, H. B. Yang, and B. Liu, “Spatially branched hierarchical ZnO nanorod-TiO, J. W. Rasmussen, E. Martinez, P. Louka, and D. G. Wingett, “Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications,”, Z. Y. Zhang and H. M. Xiong, “Photoluminescent ZnO nanoparticles and their biological applications,”, S. Kim, S. Y. Lee, and H. J. Cho, “Doxorubicin-wrapped zinc oxide nanoclusters for the therapy of colorectal adenocarcinoma,”, H. M. Xiong, “ZnO nanoparticles applied to bioimaging and drug delivery,”, M. A. Majeed Khan, M. Wasi Khan, M. Alhoshan, M. S. AlSalhi, and A. S. Aldwayyan, “Influences of Co doping on the structural and optical properties of ZnO nanostructured,”, G. Bisht, S. Rayamajhi, B. Kc, S. N. Paudel, D. Karna, and B. G. Shrestha, “Synthesis, characterization, and study of in vitro cytotoxicity of ZnO-Fe, S. Bettini, R. Pagano, V. Bonfrate et al., “Promising piezoelectric properties of new ZnO@octadecylamine adduct,”, R. Pagano, A. Quarta, S. Pal, A. Licciulli, L. Valli, and S. Bettini, “Enhanced solar-driven applications of ZnO@Ag patchy nanoparticles,”, S. Bettini, R. Pagano, L. Valli, and G. Giancane, “Enhancement of open circuit voltage of a ZnO-based dye-sensitized solar cell by means of piezotronic effect,”, L. Spanhel and M. A. Anderson, “Semiconductor clusters in the sol-gel process-quantized aggregation, gelation, and crystal-growth in concentrated ZnO colloids,”, S. Rani, P. Suri, P. Shishodia, and R. Mehra, “Synthesis of nanocrystalline ZnO powder via sol–gel route for dye-sensitized solar cells,”, Z. J. Wang, H. M. Zhang, L. G. Zhang, J. S. Yuan, S. G. Yan, and C. Y. Wang, “Low-temperature synthesis of ZnO nanoparticles by solid-state pyrolytic reaction,”, L. Shen, N. Bao, K. Yanagisawa, K. Domen, A. Gupta, and C. A. Grimes, “Direct synthesis of ZnO nanoparticles by a solution-free mechanochemical reaction,”, S. K. Pardeshi and A. The important biomedical applications of zinc oxide nanoparticles are listed as below:- 1. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. synthesized PEG-modified ZnO NPs and tested it against different breast cancer cell lines [74]. Using a simple sol-gel method, Xiong et al. Our Zinc Oxide (ZnO) nanoparticles portfolio consist of particles with diameters ranging from 16 to 40 nanometers and find applications in several industries. Zinc oxide is known to protect the stomach and intestinal tract from damage by E. coli [ 65 ]. Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity. We evaluate the potential of zinc oxide nanoparticles as innovative anti-tumor agents by summarizing important results of current studies in this field and discuss the proposed mechanisms that give zinc oxide nanoparticles a selective toxicity for tumor cells. Zinc oxide nanoparticles (ZnO NPs) ZnO NPs have long been discovered to have excellent physico-chemical properties as drug delivery vehicles. In addition, it can be coated on various substrates to prevent bacteria from adhering, spreading, and breeding in medical devices. Corresponding authors, a with the reproduced material. Zhang et al. employed natural extract of red sandalwood (RSW) as an effective antidiabetic agent in conjugation with ZnO NPs. Furthermore, it sheds light on the importance of zinc under physiological conditions. The results proved that the occurrence of autophagy in cancer cells was related to intracellular ROS generation. Jiang et al. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Among other metal nanoparticles, zinc oxide nanoparticles are very much important due to their utilization in gas sensors, biosensors, cosmetics, drug-delivery systems, and so forth. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger exc… By targeting the specific sites of cancer cells, nanoparticle-based drug delivery could reduce the overall amount of drugs used and thus minimize undesirable side effects [9, 66]. The antidiabetic activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [103]. Zinc oxide is characterized by a good biocompatibility which allows the exploitation of its antibacterial, antifungal, antiviral, and anti-cancer qualities in a therapeutic setting. 48.Goh EG, Xu X, McCormick PG. Kitture et al. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. As shown in Figure 3, within human hepatoma cells, ZnO-1 (derived from LiOH) with an average size of 3 nm showed green fluorescence, while ZnO-2 (derived from NaOH) with an average size of 4 nm appeared yellow. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the impairment of the skin-barrier functions, which was involved with complex interaction between genetic and environmental factors [112, 113]. Please enable JavaScript 2018; 30(2): 168-175. From ICP-AES measurement, the amount of Zn2+ released from the small ZnO NPs were much higher than large ZnO powder sample and E. coli was more sensitive to Zn2+ than S. aureus. Namvar et al. Taking into account these advantages, ZnO NPs can be selected as biocompatible and biodegradable nanoplatforms and can also be explored for cancer treatment [36, 37]. To improve the solubility of Zn in Zn fertilizers plays an important nutrient in organisms... Textiles have the longest and most intense contact with the human skin for drug discovery and delivery to [! Was assessed with the human skin cells, plenty of functionalization techniques have been used to prepare nanocomposites! 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